Cakemail is a Canadian-based email marketing service with a focus on two main value propositions:
Cakemail's pricing is reasonable and competitive; Buttondown is a little bit cheaper at most price points, but it is not a dramatic difference.
Cakemail offers some functionality that Buttondown does not, such as automated workflows with complex branching logic for drip campaigns and A/B testing.
However, if you're not interested in those features — which are largely the domain of enterprise use cases — then Buttondown may be a better fit to let you quickly and easily set up your newsletter and then go back to really running your business.
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Host on custom domain  | Cakemail —  | Buttondown  | 
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Dedicated IP  | Cakemail —  | Buttondown  |