Friday's Elk

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Friday's Elk: Scrapping Science on Radiolab

Last week, I talked to Latif Miller and Lulu Miller, the hosts of Radiolab, about this newsletter—in particular, how I’ve been tracking the dismantling of US science and medicine. They folded our conversation into their latest episode, out today.

Their episode drives home how a lot of the things we take for granted today emerged out of basic scientific research decades ago. But no one who did that research could predict how their findings would inspire applications. The scientists just did the work out of curiosity. That PCR test that showed you had Covid? It emerged from the search for life in Yellowstone hot springs in the 1960s—a search supported by the National Science Foundation.

I show up at around 35:00 in the episode to connect that story to what’s happening right now, explaining how the ongoing cuts and chaos threaten the basic-research pipeline.

After I finished talking to Latif and Lulu, I sent them a stream of emails as more news came out. I wanted to let them know about even more dire developments in what was already a dire story. Here is the latest:

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#188
April 25, 2025
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Friday's Elk: Decimation

As we head into the third month of the new Trump administration, some of the damage that it is inflicting on American science and medicine is starting to look irreversible. People are going to die, data is going to vanish, careers are going to end, and the benefits of a vibrant scientific community in the United States are going to dwindle, perhaps for decades.

Launching my book AIR-BORNE made it hard for me to pitch in on reporting this seismic event. But since my last newsletter I’ve been finding time to help out a little.

My first piece, co-authored with Apoorva Mandalvilli, feels like a sad epilogue to some of the reporting I did back in 2020, when scientists were scrambling to find vaccines and antivirals to fight Covid. They created effective vaccines in under a year that saved tens of millions of lives. It proved harder to develop the first drugs that reduce the risk of death from an infection of SARS-CoV-2, but eventually they created Paxlovid and other compounds.

At the time, those scientists knew very well that Covid would not be the last pandemic the world will face. They were already thinking about how we might prepare ourselves better for the next onslaught. Some researchers started designing new vaccines they hoped would provide protection against a wide range of coronaviruses that might spill over from an animal in the years to come. Other scientists developed a new generation of antivirals to work against entire families of viruses—some for coronaviruses, others for viruses that cause diseases like Ebola or influenza.

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#187
April 4, 2025
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Friday's Elk: The Two Month Mark

Two months into President Trump’s second administration, American science and medicine are now in a state that’s both dire and ambiguous. Some of the government scientists who were fired in the past few weeks are back at work. Others have ended up in a limbo of administrative leave. Others will probably never come back. The National Institutes of Health has picked up its review of grant applications, but it is lagging far behind previous years. Meanwhile, approved grants are still getting erased.

The murky picture makes it impossible to make hard and fast predictions about what American science and medicine will be like in the future. But chaos and temporary disruptions are enough to leave marks. And some of those marks are going to cut deep.

Here are a few developments since my last email that point to lasting damage.

—The head of Africa CDC said a sharp drop in outside funding, spurred by a broad shutdown in most foreign aid by the Trump administration, will lead to two million to four million more deaths each year. CIDRAP has the story.

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#186
March 21, 2025
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Friday's Elk: The Turbulence Continues

It’s time for another double-feature email. First let me run through the latest shocks that the Trump administration has inflicted on American science and medicine. All the spectacle in the news these days can make it easy to miss how dire a state we’ve ended up in. And then I’ll pivot to happier personal news about podcasts and more AIR-BORNE fun.

—Measles (a quintessential airborne disease, by the way) is having a moment in the United States. An outbreak in the west Texas region has reached at least 159 cases, with more cases popping up as far away as New York. One child died of measles in Texas, and a second person has died with measles in New Mexico. The second death is still being investigated.

—HHS Secretary Robert Kennedy initially brushed off the outbreak, calling it “not unusual.” It is unusual. The last time someone died of measles in the United States was 2015. And the time before that was 2003. Now we may have had two deaths in little over a week. Kennedy then offered lukewarm encouragement for measles vaccination. He also suggested taking cod liver oil.

—Meanwhile Kennedy canceled a flu vaccine meeting to select strains for next season.

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#185
March 7, 2025
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Friday's Elk: Air-Borne taking flight (in some really rough weather)

AIR-BORNE is coming out on Tuesday! After working on this book for three years, I’m very excited for people to finally read it. I am also eager to share some news about AIR-BORNE.

But first things first.

Let’s catch up on all the news about science and medicine in the United States since my last email two weeks ago. In that brief time, things have gone from bad to worse.

—It was startling enough when an influenza virus jumped last year from birds to cows. Now it turns out that H5N1 has jumped into cows at least three times.

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#184
February 21, 2025
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Friday's Elk: Throttling Science

Since I sent out my last newsletter, the Trump Administration has moved to drastically shrink government support for American science and public health. And they have announced plans for more such changes. Here are just a few examples:

—The Trump Administration is shutting down USAID, thereby killing off clinical trials around the world, crippling US efforts to investigate an Ebola outbreak in Uganda, and halting efforts to block malaria.

—As I write this, PEPFAR, which has saved an estimated 25 million lives by distributing HIV drugs in Africa, is effectively frozen.

—The Trump Administration announced a new policy to severely curtail grants from the National Institutes of Health.

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#183
February 8, 2025
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Friday's Elk: Five Years of Covid, A Mirror Pandemic, And More

New Year’s Eve will never be the same. On December 31, 2019, my wife Grace and I were hosting friends at our home in Connecticut, playing board games with their kids and clinking glasses at midnight to mark the arrival of a new decade. We celebrated in cheerful oblivion of a New Year’s Eve announcement from Wuhan. Earlier that day, the city’s health commission issued a public notice of a small outbreak of viral pneumonia.

“So far the investigation has not found any obvious human‑to‑­human transmission,” the commission declared.

In fact, a few doctors around Wuhan had already concluded that this was exactly how the new coronavirus was spreading. “At the end of December, the signs of human‑to‑human transmission were already very obvious,” Zhang Li, a doctor at Jinyintan Hospital later recalled. “Anyone with a little common sense could reach that assessment.” With some help from modern transportation, human-to-human transmission then spread Covid out of Wuhan and around the world. It became the worst pandemic crisis in modern history.

This week marks the fifth anniversary of Covid’s official debut. Since it emerged, the disease has killed perhaps over 27 million people. In 2020, Covid became the third highest cause of death in the United States, trailing only cancer and heart disease. It held onto third place in 2021, slipping to fourth place in 2022. In time, vaccinations and immunity from previous infections made Covid less deadly. In 2023, it slipped to tenth place in the list of U.S. deaths.

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#182
January 3, 2025
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Friday's Elk: The Air-Borne Tour Takes Shape!

When the Covid pandemic hit in early 2020, I got a call from Jad Abumrad, the creator of the podcast Radiolab. In previous years, I had helped him on a number of episodes—about everything from the speed of thought to giant viruses. Now Jad was thinking about what he and his team of producers could offer in the midst of a planetary crisis.

I suggested that he could tell the story of Ignaz Semmelweis, the brilliant, troubled nineteenth-century doctor who recognized that hand-washing could break the deadly chain of disease. Jad invited me to help him create an episode about Semmelweis, which ended with my urging people today to follow his example and break the pandemic’s spread by washing their hands.

Washing your hands is unquestionably a good way to stay healthy. But Covid forced the world to take another look at how to avoid getting sick. Even with clean hands, it’s now very clear, you can inhale an infectious dose of coronaviruses.

As the airborne nature of Covid emerged, I began to explore the fascinating history of our understanding of life in the air. The result was my next book AIR-BORNE. I’m delighted that I can start sharing details about events I have planned to celebrate the launch.

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#181
December 6, 2024
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Friday's Elk: Feeling Like 2016 All Over Again

Last week, I traveled to Italy to give a talk about viruses at the Genoa Science Festival. I ate a lot of focaccia and a lot of pesto, as one should in the city where both those fine dishes were invented. And I was also interviewed on Italian radio and television. The journalists asked me about my book A Planet of Viruses, which was translated into Italian last year. But the conversations inevitably turned to American politics.

I had no idea at the time who would win the presidential election. But I expected that the choice would have a huge impact on American science and medicine. During his campaign, Donald Trump promised that Robert F. Kennedy Jr.—a man who lacks any medical or scientific training and who has promulgated false claims about medicine—would have free rein over America’s health. Trump himself also has a long track record of dismissing climate change, either as a hoax or an insignificant distraction.

I suppose some people might brush all this off as campaign talk. But we have four years of a previous Trump administration to examine as a prelude. Here’s a talk that I gave seven years ago about Trump and science, and how journalists should respond. At the time, he was installing climate deniers in his administration and shutting down public web pages about climate change.

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#180
November 8, 2024
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Friday's Elk: French Fries And The Evolving Natural

Potatoes

French Fries And The Evolving Natural

My doctor recently advised me to cut down on the carbs. While my blood sugar level is thankfully still safe, it’s inching up as I march through middle age. So I am trying my best to resist things like French fries.

Following my doctor’s advice feels like a struggle against the modern world. The twenty-first century food industry provides much of humanity with cheap, tasty carbohydrates that are helping to drive pandemics of diabetes and other disorders.

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#179
October 18, 2024
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Friday's Elk: The Lost Scientists of the Sky (and Autumn Talks)

This week, I wrote in the New York Times about a newly published study on the life that floats 10,000 feet over Japan. A team of scientists chasing after the cause of a mysterious disease got in a Cessna equipped with vents, tubes, and filters. They then flew into the sky in pursuit of living things.

A plane in the sky
Photos courtesy of Xavier Rodo

After they returned to Earth, the scientists suited up in biosafety gear to inspect their harvest.

Scientist inspecting airplane filter
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#178
September 20, 2024
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Friday's Elk: AIR-BORNE gets a cover. And Lucy turns 50.

My next book, AIR-BORNE, will be coming out in February. You’ll be able to recognize it in your local bookstore by its groovy cover:

If the cover looks surreal, that’s no accident. Aerobiology—the science of airborne life——has shown us that the atmosphere is eerily alive, from the breath you just inhaled to the clouds that float overhead. I hope when you’re done reading AIR-BORNE, the sky will look different—a floating garden rather than a desert.

You can pre-order AIR-BORNE now. I will share updates as the publication date approaches both here and on a new page on my website.

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#177
August 16, 2024
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Friday's Elk: Introducing AIR-BORNE, my next book!

A dust storm moved over a town
Haboob over Arizona. Photo by Gerald Ferguson, via Twitter

It’s Coming!

A few days ago, I sent my publisher the final polishes to my next book, AIR-BORNE: The Hidden History of the Life We Breathe. I’ve kept pretty mum about the project for the past couple years while I’ve been researching and writing it. But now you can officially pre-order a copy. So I’m delighted to send you this email to tell you about the book.

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#176
August 2, 2024
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Friday's Elk: Just When I Thought I Was Out...

These days I spend some of my time talking to virologists about a new virus that can move from quickly host to host. It uses a route that we don’t yet understand very well. But we need to find out, because the virus has an unknown potential to wreak havoc on the economy and to give rise to a new pandemic. I’m keeping tabs on companies scrambling to design new vaccines against the new virus, drawing up plans to manufacture them in huge quantities if needed in an emergency.

I am not reporting about Covid-19 (which is not to say Covid-19 is gone, of course). Instead, I’ve started helping the New York Times with its reporting on a strain of H5N1 avian influenza that’s spreading among cows.

I’m glad to pitch in, because it’s a story that needs telling. But I really wish my colleagues and I didn’t have to tell it. I especially wish that I didn’t hear so many echoes from early 2020, at the start of the Covid-19 pandemic.

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#175
July 5, 2024
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Friday's Elk: Life Keeps Throwing More Junk at Us

Life Keeps Throwing More Junk at Us

It’s been nearly ten years, but I can still see the blood flowing out of my finger.

Onions

I was in a lab in Canada, chopping the green stem of an onion with a razor blade. I accidentally brought the ring finger of my free hand too close and I slit open my skin. The scientists looking over my shoulder with didn’t flinch. One of them, Nick Jeffery, just raised a vial to my finger and had me skim off a few drops. They needed my blood anyway, for an experiment they were about to carry out.

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#174
June 7, 2024
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Friday's Elk: Why Do Whales Sing? Why Do We Sing, For That Matter?

Why Do Whales Sing? Why Do We Sing, For That Matter?

A pod of sperm whales

In my work as a journalist, the threads of science sometimes weave together in unexpected ways. For some time now, I have been keeping an eye on a team of scientists studying whales, in the hopes of deciphering their songs with signal analysis, machine learning, and other methods from computer science. The team, which calls itself Project CETI, formed four years ago, and they’re just now starting to publish the first results of their work.

It’s been nearly 60 years since biologists first recognized that humpback whales produced strange whoops and rattles that lasted for hours at a time. Whale songs became cultural icons on best-selling albums, in Star Trek movies, and on the Golden Record that NASA flung into deep space. Other whales, scientists discovered in later decades, produce their own songs. The songs are not rigid, simple calls; they turned out to be complex and creative acts. But their meaning remained a mystery.

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#173
May 24, 2024
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Friday's Elk, May 10, 2024

The Brain Worm Edition

As I was sitting down to write this email, I learned that my book Parasite Rex got name-checked today in a podcast (44:20). It’s not a podcast about biology, mind you, but one about politics. In a conversation about tapeworms and Robert F. Kennedy Jr.’s brain, one of the hosts recommended the book for learning more about parasites.

We authors will take a plug pretty much anywhere we can get one. But I did not expect a plug to arrive at such a weird cultural moment—a moment in which which Stephen Colbert is making jokes about a tiny voice in RFK’s head asking, “What wine pairs best with cerebellum?”

The reason for all this parasitological palaver was a story that my Times colleague Susan Craig broke earlier this week about Kennedy’s health. Looking at a deposition, Craig learned Kennedy had trouble with his memory. A doctor, according to Kennedy, said it “was caused by a worm that got into my brain and ate a portion of it and then died.”

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#172
May 10, 2024
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Friday's Elk, April 26, 2024

Welcome to another edition of "Friday's Elk." I'm sending out this newsletter every other week, barring deadlines and such. It's free, but any support you may want to offer will be most appreciated!

Cicadas: Inescapable Yet Elusive

If you live east of the Rockies in the United States, there’s a decent chance that you’ve witnessed one of nature’s weirder happenings: the emergence of trillions of cicadas.

a cicada on a leaf
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#171
April 26, 2024
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Friday's Elk, April 13, 2024

Welcome to another edition of "Friday's Elk." I'm sending out this newsletter every other week, barring deadlines and such. It's free, but any support you may want to offer will be most appreciated!

A Science Writer in Florence

Since my last newsletter, I turned in a revised draft of my next book (more details soon!) and headed off with my family to Florence. I had never been there before, and it did not disappoint. It is almost absurdly rich with the histories of art, business, and politics. And it's got plenty of history for a science writer, too.

After all, Florence was Galileo's home for many years. If you end up in Florence someday, I highly recommend a trip to the Galileo Museum, where you can see a lot of exquisitely beautiful scientific instruments, such as a sixteenth-century armillary sphere, which places Earth at the center of the cosmos. I zoomed in for a picture that would capture its awesome intricacy.

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#170
April 13, 2024
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Friday's Elk, March 22, 2024

Welcome to another edition of "Friday's Elk." I'm sending out this newsletter every other week, barring deadlines and such. It's free, but I will appreciate any support you may want to offer!

LifeGPT?

In early 2020, as the world plunged into the Covid-19 pandemic, I spent a lot of time thinking about what it means to be alive. The SARS-CoV-2 coronavirus was, depending on who you asked, a living thing or a non-living menace.

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#169
March 22, 2024
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Friday's Elk, March 8, 2024

Welcome to another edition of "Friday's Elk." I'm sending out this newsletter every other week, barring deadlines and such. It'll stay free, but any support will be much appreciated!

Who Else Is In Our Species?

If you're reading this--and if you have neurons for brains rather than microprocessors--I'm going to assume you're a member of my species, Homo sapiens. No other living species has ever shown a capacity for reading email newsletters.

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#168
March 8, 2024
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Friday's Elk, February 16, 2024

Welcome to another edition of "Friday's Elk." I'm sending out this newsletter every other week, barring deadlines and such. It'll stay free, but any support will be much appreciated!

Jurassic Ostrich?

Scientists who study the origin of birds in 2024 live in a different world than those who were studying it in 1994. In 1996, paleontologists in China announced the discovery of the first dinosaur with primitive feathers. Then more fossils came to light, some with more bird-like feathers. There were dinosaurs with stripes of colors across their plumage. They sported feathery tails, even feathery legs.

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#167
February 16, 2024
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Friday's Elk, February 2, 2024

Welcome to another edition of "Friday's Elk." I'm settling down here at my new home at Buttondown and hope to send this newsletter out on a fairly frequent basis. It'll stay free, but any support will be much appreciated!

X Marks Many Spots

It's been so long since I learned about the X chromosome that I can't remember when I became aware of it. It's one of the first things we learn about genetics, because the basics are so basic. We have 23 pairs of chromosomes, 22 of which are identical. The 23rd pair are the sex chromosomes: in females, two X's, and in males an X and a Y. Done.

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#166
February 2, 2024
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Friday's Elk, January 12, 2024

Why The Magic?

One of the most surprising recent trends I've noticed in science news is the explosion of stories about magic mushrooms. Of course, this is old news for people across Latin America who have consumed the fungi in rituals for thousands of years. It was only in 1957 that many Americans became aware of psilocybin, the active compound in magic mushrooms. In an article for Life magazine a J.P. Morgan banker named Robert Gordon Wasson recounted how a Mexican shaman provided him with the legendary substance. "For the first time the word ecstasy took on real meaning," Wasson reported.

To Wasson's regret, the article brought a flood of hippies to Mexico seeking to copy his experience. The counterculture popularity of the mushrooms led the U.S. government in 1971 to designated them a Schedule 1 controlled substance. A hidden culture grew around the illegal fungi like a subterranean web of mycelia.

Today, over half a century later, they're still officially illegal for the most part. But in recent years some scientists have begun carrying out studies to understand how exactly they produce ecstasy in the human brain. Psychiatrists are investigating them as a way to treat patients for with depression, PTSD, and other conditions. (A few months ago, I had a fascinating conversation at the Crosscut Festival in Seattle with two psychiatrists in the midst of this work. You can listen to it here.)

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#165
January 12, 2024
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Friday's Elk, December 29, 2023

The Sisyphus Tree

With just two days left in 2023, I have been looking back over the year in biology, scanning for news that pops out.

There were some stories of long-dreamed triumphs. In late 2023, both the United States and the United Kingdom gave the green light to CRISPR as a medical treatment for the first time.

Back in the 1990s, CRISPR first came to light as a kind of immune system for bacteria. The microbes made molecules that zeroed in on viruses, shredding their genes. Scientists converted those molecules into a tool for editing DNA in human cells. With CRISPR, researchers rewrote genes in the blood cells of people with sickle cell anemia and other blood disorders, reversing their diseases. Newer forms of CRISPR may very well cure other diseases in the years to come. (Here is a piece I wrote for Quanta and another for the New York Times, both on the history of CRISPR.)

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#164
December 29, 2023
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Friday's Elk, December 15, 2023

Greetings! This is the newly reincarnated version of my long-running newsletter.

If you have come here for the first time, welcome to what I hope you will find an entertaining and edifying experience. I write the "Origins" column for the New York Times, and I write books about science (fifteen so far). In my newsletter, I riff on the subjects and ideas that grip me in those longer works. I also send out links to talks I give (in person, on the radio, online), as well as to things I've published.

If you are a long-time reader of "Friday's Elk," welcome back! You are no doubt noticing something different about it. For a number of years, I used a service called Tiny Letter to send out my newsletter. But now its provider is shutting it down and offering alternative plans that just don't suit me.

Wondering what to do next, I noticed that other writers I know and respect, such as Annalee Newitz and Ed Yong, were using a service called Buttondown. After checking it out, I decided that it would suit me too. So I've taken the liberty of rolling all you Tiny Letter subscribers into my new Buttondown list.

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#163
December 15, 2023
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Friday's Elk, December 1, 2023


Greetings--

As 2023 approaches a close, I have a few things to share.

Books: With the holidays on the way, I have some remaining books to offer if you're gift-hunting for someone who likes to read about science. I'm happy to sign them to friends and loved ones! Check out the options here.

Best of American Science and Nature Writing: Please join me on December 11 for a Science Friday event. I'll be part of a lively discussion about some of the finest stories that came out this year, including two writers I selected for this year's edition of the anthology. Register here for the livestream.
Microsleeping penguins and other surprises of nature: Since my last email, I've published pieces on penguins taking thousands of naps a day, bonobos welcoming outsiders (which is weirder than you might think), Omicron turning two, human history as told by lice, and the evolutionary mystery of menopause.

Friday's Elk will be getting a new home: For the past few years, I've been using Tiny Letter to send out this newsletter. Alas, Tiny Letter is about to evaporate. I've decided to roll Friday's Elk over to a highly recommended host called Buttondown. So you can expect the next dispatch from there. Friday's Elk will have a somewhat new look in its new incarnation, but it will remain free and (I hope) no less interesting.

That's all for now. Stay safe!

You can find out more about all my books here. 
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#162
November 30, 2023
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Friday's Elk, October 20, 2023

Greetings! To kick off today's newsletter, I have a couple things to share about books.

First off, the 2023 edition of the Best of American Science and Nature Writing hit book stores this week. I'm very honored to have had the chance to edit it this year, and I think you'll enjoy the selection of stories I picked. There's a lot in the book on Covid, of course, and about climate change, naturally--but there's lots other stuff to read, like an epic about swimming cows. “Readers will be enthralled,” Publisher's Weekly promises. You can find the book in stores and on Amazon, Barnes & Noble's, and Bookshop.

Also, as the gift-giving season approaches, I have some copies of my previous books to autograph. They included Life's Edge, She Has Her Mother's Laugh, and Soul Made Flesh. You can order them with personalized autographs via this Google Form. Postage is included in the cost ($10 for paperbacks, $15 for hardbacks). I'm using PayPal for payment and will send them to domestic US address. (No international orders, I'm afraid.) If you have any trouble with this process, contact me via my web site.

On the journalism front, I've published several columns since the last newsletter. Following up on a story I wrote last year about the microbiome that might lurk inside tumors, I wrote about a new debate about how how reliable the studies are. I also wrote about the thousands of cell types in our brains, why some mammals engage in same-sex sexual behaviors, more bizarre surprises from the world of contagious cancer, how human ancestors nearly vanished about a million years ago, why all mammals may vanish 250 million years from now, and a remarkable discovery of ancient woodworking.

Finally, an announcement for people around Boston. On Monday October 30, I'm coming back to the Coolidge Corner Theater for their fantastic Science on Screen series. They'll be showing Death Becomes Her, the 1992 dark comedy about immortality starring Meryl Streep and Goldie Hawn. I'll give a talk beforehand about the strange science of aging and attempts to reverse it. Details here.

That's all for now. Stay safe! 

You can find out more about all my books here. If you received this email from a friend, you can subscribe to it here. You can follow me on Mastodon, Bluesky, LinkedIn, Goodreads, and Facebook.
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#161
October 19, 2023
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Friday's Elk, August 15, 2023


Greetings! Here is a quick midsummer update.

Best American Science and Nature Writing: As I mentioned in the last newsletter, I had the honor of editing this year's volume. Publisher's Weekly just gave it a starred review. "Readers will be enthralled," they say. If you'd like to be enthralled, you can pre-order it now.

The endless parade of weird fossil whales: It has been 25 years since I published my first book, At the Water's Edge: Fish with Fingers, Whales With Legs, And How Life Came Ashore But Then Went Back To The Sea. I tried in the book to capture a remarkable moment in the history of science in the 1990s, when spectacular transitional fossils came to light, helping us understand some of the most dramatic transformations in the history of life. Of course even books can only be just snapshots of history, so I knew that new developments would come after it was published. Still, I was astonished to learn last month of a huge early whale that may have been the heaviest animal to ever live. Here's my story of the perplexing Perucetus. 

(Image by Alberto Gennari)

Blood boys and epigenetic clocks: The urge to live forever never dies. There's always something new to buy that will supposedly stop your biological aging. While it's wise to stay suspicious of these products, that doesn't mean that there isn't some fascinating work on aging taking place. I wrote about two interesting lines of research: the rejuvenating power of young blood, and the relentless ticking of the epigenetic clock.

More stories! A bet on consciousness. A controversy over a hominin graveyard. A bunch of human embryo models. A debate about the evolution of human pregnancy. Using DNA to join enslaved African Americans to their living relatives.

That's all for now.

You can find out more about all my books here. If you received this email from a friend, you can subscribe to it here. You can follow me on Mastodon, Bluesky, LinkedIn, Goodreads, and Facebook. I still keep an account on Twitter, but mostly out of nostalgia at this point.

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#160
August 14, 2023
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Friday's Elk June 3, 2023


Greetings on the cusp of summer! I am still chugging away on my next book, digging into archives, paying visits to scientists, and otherwise trying to reconstruct the past. I'm very eager to share details, but I'll have to wait until I've lashed down this unruly manuscript.

In the meantime, I'm pleased to share a couple pieces of news. To start off, I can now share the cover of the this year's Best of Science and Nature Writing. The book comes out in October, but you can order it now.

It was an honor to serve as editor for 2023. I have assigned editions of this book for years in my writing classes, and so editing it felt not just like an honor, but as a long overdue payback. I enjoyed picking out stories that embody the state of science and nature writing today, some from writers I've long admired, and some I discovered for the first time while working on this book. (Thanks to Jaime Green for overseeing the process, even as she launched her own excellent book, The Possibility of Life.) 

Meanwhile, my work at the New York Times is...evolving, shall we say?

It's shocking that ten years have passed since I published my first weekly "Matter" column for the Times. According to the tag line my editors came up with back in 2013, "Matter" would be a "weekly column about the stuff of everything." I appreciated the wide berth that afforded me. While I was able to write about what I wanted to write about, what I wanted to write about often had to do, in one way or another, with evolution--human origins, the origin of life, the origins of brains, and so on. I also stretched out to write about ecology, climate change, forever chemicals, and--for over two years--all things Covid. 

After a decade, my editors and I agreed it was time to look again at what I wanted to do with the column and the rest of my work at the Times. I'm renaming the column "Origins." The tag line is now "on life, species and how things came to be." For my first column, I'm returning to one of the origins that has fascinated me for a long, long time as a journalist: the origin of birds.

(Art by Michael Rothman)
One point I sought to make in the essay was that the origin of birds did not occur at one moment in time. It was the assembly of a body plan over a very long time--long before dinosaurs took to the air. The birds in the pictures above lived 125 million years ago, and while they seem basically like the birds we see today, they actually belonged to a separate branch that vanished in the great extinctions 66 million years ago. 

I'll still be writing other stories, but they will appear as straight news, rather than as a column. My editors will still be giving me a lot of freedom in my choices of subjects, so if there's something in nature that you look at and wondering, "Where did that ever come from?" please reach out!

That’s all for now. Stay safe!

You can find out more about all my books here. If you received this email from a friend, you can subscribe to it here. You can follow me on Mastodon, Bluesky, Spoutible, LinkedIn, Goodreads, and Facebook. I still keep an account on Twitter, but mostly out of nostalgia at this point.
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#159
June 2, 2023
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Friday's Elk, December 30, 2022

With the end of 2022 coming tomorrow, I'm struck by how this year made Covid weirdly familiar.

At the end of 2019, the earliest reports were coming out of Wuhan of a puzzling new pneumonia besetting hospitals. The world soon shut down, as the virus flew from country to country.

At end of 2020, effective vaccines were getting shot into arms. They have saved many millions of lives worldwide. But the end of 2020 unfortunately also brought a striking demonstration of evolution in action: a new variant, which came to be known as Alpha, started surging to dominance.

At the end of 2021, a different variant was surging. Omicron wiped out Alpha, and all the other variants that had come before. Its mutations allowed it to evade some of the immunity provided by the vaccines, although the vaccines still dramatically reduced the risk of severe disease.

At the end of 2022, we are still living in the Age of Omicron, although its descendants have evolved into a staggering menagerie of subvariants, some of which are far better than 2021's Omicron at spreading. Their advantage comes partly from mutations that let them evade the antibodies we have gained either from vaccines or earlier infections. But they also appear to have other mutations that help them bind more successfully to cells, making them more transmissible.

At the end of 2022, we know that booster shots can provide extra protection, especially for the elderly and others at high risk of serious disease. This year, the United States tried to catch up with evolution by authorizing a booster that included the BA.5 subvariant of Omicron. It's not clear how much extra protection it offers beyond a booster against the virus as it existed at the end of 2020. BA.5 dominated much of the world for a few months of 2022, but now it's being outcompeted by new kids like XBB.1 and BQ.1.1.

At the end of 2022, people are back at offices, going to restaurants, and catching movies--in other words, revising the places where indoor air can harbor floating droplets expelled by people infected with Covid. Masks are rarer. Testing has slacked off.

Yet at the end of 2022, Covid remains a major threat. That is nowhere more obvious than in China, which has spent much of the past three years locked down. While China has notoriously unreliable Covid statistics, a number of studies suggest that it has experienced far fewer deaths than other major countries. But that success came at a brutal cost, with millions of people trapped in their homes for weeks or months at a time. Nor did China make good use of that time. They achieved fairly low rates of vaccination in elderly people--the ones at greatest risk from Covid. They also went all in on Chinese vaccines made from inactivated viruses, which don't appear to be as effective as vaccines based either on proteins or mRNA. As China abruptly drops many of its restrictions, a highly evolved version of the coronavirus is going to sweep through a population that has a weak wall of immunity.

All the attention now focused on China may produce the false sense that everything is fine elsewhere, that other countries are magically past the pandemic. The numbers say otherwise. In 2020, over 350,000 people died in the United States alone. But over 739,000 Americans have died since then, and well over 2,000 are currently dying of Covid every week.

I hope that things don't get worse in 2023. But I also hope that we don't fatalistically leave things to unfold on their own. Many public health measures can lower transmission, as well as hospitalizations and death. But so can scientific advances. Looking back over the stories I wrote for the New York Times over the course of the pandemic, I am struck by how many articles in 2020 and 2021 concerned fast-moving studies that led to better weapons against Covid and raised hope for even better ones in the future. But in 2022, I didn't find much innovation to write about. As we socially swing back to normal, scientific research is also swinging back to a more ordinary pace. And so the pipeline for a new generation of vaccines, antivirals, tests, and other potent weapons against Covid has gotten gummed up. I hope I can write about more scientific advances in 2023, but I'm doubtful. On the other hand, I do know for sure that I will be writing about Covid's continued evolution.

I recently dropped by the offices of This Week in Virology, to talk to virologist and podcast host Vincent Racaniello about what it's been like to report on the pandemic so far, and what this coming year may look like. You can listen or watch here. 

This winter I'm digging deep into my next book, which will fold in some of our experience with the pandemic, but hopefully fit it into a bigger picture of history and biology. I'll have more to say about it when it's fit for sharing. In the meantime, here is Mick, our cat who is currently using my research table as a fortress of solitude, wishing you a happy, healthy 2023.

You can find information and ordering links for my all my books here. If someone shared this email with you, you can subscribe here. I am also on Mastodon, Post, Linkedin, Facebook, Goodreads, and Twitter. 


 
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#158
December 30, 2022
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Friday's Elk, November 5, 2022

In the early 1990s, the idea of ancient DNA seemed like it would forever remain the stuff of science fiction, despite the best efforts of scientists. Michael Crichton gets credit for imagining the possibility for his 1990 novel Jurassic Park, turned in to a movie three years later by Steven Spielberg. In Crichton's telling, mosquitoes feast on dinosaur blood, get trapped in amber, and millions years later offer up dinosaur DNA to science and the theme park industry.

Just a year after the movie came out, a Utah geneticist published a paper in the journal Science, describing a gene he extracted directly from an 80-millon-year-old fossil that likely belonged to a dinosaur.

As a newbie science writer at the time, I found this discovery mind-boggling. While I doubted anyone would be resurrecting dinosaurs, the ability to see the DNA of ancient organisms like dinosaurs would give paleontology an extraordinary precision. But it turned out to be too good to be true. 

In a biological self-own, the DNA proved to come from a human who handled the fossil. That a scientist could believe a snippet of human DNA came from a long-lost reptile tells you a lot about our deep ignorance of genetics at the time. Soon, other biologists were poo-poohing the idea that DNA could survive for millions of years. The whole conceit of ancient DNA seemed pointless.

But the pendulum swung back. Thanks to the sequencing of many genomes, including our own, scientists can spot contamination more accurately. They also have lots of new procedures to avoid contamination in the first place. They have learned how to squeeze DNA out of some very unpromising fossils. They can even get ancient DNA out of dirt.

Jurassic DNA may not be a thing, but Pleistocene DNA is. It can last for hundreds of thousands of years, and can tell us a lot about recent evolutionary history--including our own. Last month, Svante Paabo won the Nobel Prize for resurrecting ancient DNA from Neanderthals and other early humans.

In the wake of Paabo's prize, I published a pair of stories that give a sense of just how much detail we can now see. In Russia, Paabo and some colleagues have found a Neanderthal family, with a father and daughter linked by their genes. And in London plague cemeteries, other researchers have found evidence of natural selection at work in the Black Death.

In other news, the politics of Covid's origins continue to simmer--and will likely flare up if the GOP takes the House. Meanwhile, ongoing experiments with SARS-CoV-2 illustrate the need for clearer, stronger guidelines to ensure lab safety.

Finally, on the social media front, I'm puzzling over what to do as a journalist amidst the ongoing chaos on Twitter. I'm still @carlzimmer for now, but I'm also checking out Mastodon as @Carl_Zimmer@mastodon.social.

That's all for now. Stay safe!

You can find information and ordering links for my fourteen books here. You can also follow me on Twitter, Facebook, Goodreads, and LinkedIn. If someone forwarded this email to you, you can subscribe to it here.

Best wishes, Carl

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#157
November 5, 2022
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Friday's Elk, September 2, 2022


In February 2020, my editor at the New York Times let me know he would only be editing stories about Covid for the foreseeable future. If I wanted to pitch a story about Neanderthals or global warming, I'd need to talk to another editor. But if I had ideas for Covid stories, he wanted to hear them.

I figured I'd join the effort, since I had written about other viruses in the past. The Covid news started coming so fast that we all had to think about new ways of covering it. I put together a simple spreadsheet of all the vaccines in clinical trials, just to keep them straight in my head. My editor and I decided that could be the basis of a tracker to update with every important development. We launched it in June 2020, and soon after we launched a second tracker to keep up with news about Covid treatments.


On Wednesday, we decided it was time to stop updating them. After more than two years, the pace of news has slowed from the daily frenzy of mid-2020 to a more manageable pace. It's not that the development of vaccines and treatments has ground entirely to a halt. But it is true that a substantial fraction of efforts have either ended in success or failure, while others have simply stalled.

I shared some thoughts on Twitter on the long-term story that these trackers captured with their day-to-day updates. Scientific history was unquestionably made. Getting a new vaccine into people's arms typically takes over a decade. Pfizer and Moderna managed that feat in a year. And in the following year, a number of other effective vaccines reached the finish line as well. The chemistry involved in making a new antiviral can also stretch out over a decade or more. Pfizer scientists were able to create an effective pill for Covid, Paxlovid, in far less time than that.

But both efforts fell short in other respects. Once variants emerged in 2021, there should have been a new push for next-generation vaccines that could provide sustained protection against them. That push has yet to come. Meanwhile, the global distribution of vaccines is still limping along.

As for drugs, a lot of effort was wasted testing existing ones to see if they might work against Covid. Too often these trials were so small they couldn't reveal anything meaningful. The big ones struggled to find volunteers. As for new drugs, we shouldn't consider Paxlovid the end of the line, because the virus may evolve resistance to it. But there is no longer the same focused push towards new Covid drugs. It could be a very long time before any others get approved.

I'm grateful that I was able to work on these trackers with colleagues who were also eager to try out this new format, and who helped to keep up with developments around the world: Jonathan Corum, Katherine Wu, Matt Kristoffersen, Sui-Lee Wee, and Andrew Kramer.  Covid will remain part of my beat, but I will focus on writing articles rather than updating trackers. And there will be room for other subjects--research on other serious threats to our health, and research that is interesting simply for revealing something new about how the world works.

Over the past couple months I've been writing a mix of Covid and non-Covid stories. In case you missed them, here they are:

I wrote a story about a new treatment that can break down so-called "forever chemicals" quickly and cheaply.

Here's a story about fascinating research on whale songs, revealing how they're spreading around the world thanks to high-speed cultural evolution.

Why can some people digest milk? It's a classic case of human evolution, but some new research has led scientists to rethink the story.

In 1998, I published my first book, At the Water's Edge. I wrote about how life came on land, and later went back into the sea. One key case I described was how our fish ancestors evolved legs. In a new twist, scientists have found that one branch of vertebrates turned around right away and started swimming again.

And, finally, here's a story about the relatives of SARS-CoV-2 that are still in bats for now, and how they behave in human cells.

On a separate note: I'll be giving some talks in the months to come. I'll send updates in future emails. For now, here's a recent conversation I had about life as a science writer on the podcast Media Masters. 

That's all for now! Stay safe.
 
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#156
September 1, 2022
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Friday's Elk, July 2, 2022

I was looking forward in this issue of Friday's Elk to sharing some recent work of mine that is blissfully far from Covid. The pandemic is, of course, far from over, and I have still been pitching in at the New York Times with Covid science coverage. But I have also been grateful to work on some stories not focused on that blasted SARS-CoV-2. They remind me of how much there is to learn about the world, and how much the pandemic has narrowed everyone's experiences.

I will write about them in this email. But first, here's a reminder I got on Tuesday that the virus does not care about what we want....

Yes, I have Covid for the second time in less than six months.

My first case in January was very mild and very mysterious. I can't tell where I got it from. After an initial positive PCR test, I tested negative on a series of antigen tests and a PCR test. I felt under the weather for a few days, and then had a low-grade persistent cough for a couple weeks. End of story.

I figured my experience demonstrated two things: just how good Omicron was at infecting people, and just how good vaccines are at keeping Covid from getting really dangerous. (Here's a graph of New York State hospitalizations over the past year: blue is for unvaccinated people, red for vaccinated.)


The Omicron wave was in the middle of a fall at the time, and it kept falling through the spring. As the weather warmed, it got easier to meet with people at sidewalk tables for dinner, for drinks on patios, or just bumping into each other on the sidewalk. I adjusted my risk budget, sometimes venturing inside restaurants or stores without my mask. But when I flew to West Virginia last month to give a talk, I masked from the moment I got in a taxi to the airport until I arrived in my hotel room. And in advance of the trip, I got my second booster--even if it was a vaccine designed in 2020, when nobody thought of Omicron as anything but a Greek letter.

That all worked fine, until last Friday. I won't say exactly where I was that evening, for the sake of the privacy of the people I was with, but suffice to say it was a small local business throwing an open house. And it was great. I caught up with a bunch of people I hadn't seen in quite a while, thanks to the pandemic and to the damage the pandemic did to my social skills. I walked home with my wife thinking that this was precisely the sort of thing that I had missed since Covid showed up.

Saturday morning, our host informed us with regret that he woke up feeling ill and tested positive. We started testing ourselves, but came up negative. On Monday afternoon, I felt run down--so run down I had to take a nap. I still tested negative, making me think I might just have a bad cold. I had a night of aches and a 102 degree fever, and the next day I tested positive.

I stayed in bed for a day and a half, my fever and aches abating, leaving me with just a lot of fatigue. I binged some TV, did some reading for a new project, and got back to writing towards the end of the week. I feel fairly normal again now, but today's antigen test is comically aggressive. This is what it looked like a few SECONDS after I put the swab in the cartridge: the positive line was a deep burgundy banner while the control line was just starting to form.
The version of Omicron I got infected with in January--probably the subvariant BA.1--clearly didn't protect me against reinfection. I wouldn't be surprised if I got hit last week with BA.4 or BA.5, which are surging here in Connecticut and can evade immunity from earlier forms of the virus. There's no reason to rule out more subvariants--or some other variant entirely--evolving in the months to come and creating a new risk of reinfection.

Still, my combination of a previous infection and vaccinations dramatically reduced my odds of getting a severe case of Covid, and for that I'm grateful. But getting Covid a few times a year is not a prospect I relish. A Covid infection, even a mild one, brings with it a risk of long-running symptoms such as brain fog and fatigue. And some new research indicates that repeated infections raises the subsequent risk for a lot of bad outcomes like heart attacks and strokes. Dr. Bob Wachter of the University of California San Francisco summed up the current research the other day in this piece for the Washington Post.

The spring decline in the United States stalled in April, and we've climbed to a plateau of about 100,000 new reported cases every day. I'm sure that the real number is far higher, since at-home tests rarely get reported and the positivity rate is high pretty much everywhere. It would be nice, 2.5 years into the pandemic, for the country to do regular randomized covid surveys, so scientists could make good estimates of the fraction of people in the U.S. with an infection. The United Kingdom does this fairly well, and the results are striking. Officially, the U.K. is logging about 20,000 new cases a day. But 3.35% of people in the survey turn out to have covid, which means that about 1.8 million Brits are actually positive.

Things could well get worse in the fall, when people start heading inside, immunity from earlier vaccines wane, and new subvariants possibly arrive. The U.S. government is making moves to get more people boosted, but companies are only just starting to test vaccines tailored for BA.4 and BA.5. By the time they'd be ready in the fall, will we be dealing with BA.7?

Isolation while I'm infected is a drag, a stark contrast from the happy party where I got infected in the first place. And once I finally test clear of the virus, I will probably dial back my social interactions, paring down my risk budget. Which is not what I had expected to be doing in summer 2022. 

I wish you good luck in evading this virus and cobbling together a good summer in spite of it. And now, as promised at the top of the email, here are a few things to take your mind off the pandemic:

On Monday, I wrote about the first decade of CRISPR. I've been reporting on this genome-editing technology for years--in this 2015 piece for Quanta, for example, and at more length in She Has Her Mother's Laugh in 2018. Observing its development has been astonishing. It's important not to think of CRISPR as magic that has solved all our problems, or as a limitless power to do harm. But it's also important to recognize its progress. For example, ten years after CRISPR was first demonstrated as a potential tool, at least one company is on the verge of applying to the FDA to use it to reverse a hereditary disease.

Today, I look into a subject I explored last year in Life's Edge: how can we know if there's life on other planets? The James Webb Space Telescope, launched this Christmas, is just now starting to look at planets around other stars. It may be able to determine if they have atmospheres that could support life--the first step to the possible discovery of a biosignature. 

I also wrote this month about some weird tiny life here on Earth. First, a virus that has wiped out hundreds of millions of rabbits in Australia--and thereby serves as a warning that viruses do not necessarily evolve to be more benign. And giant bacteria, the size and shape of your eyebrows, hiding in plain sight all this time.

It's almost enough to make you forget you have Covid!

That’s all for now. Stay safe.

You can information and ordering links for all my books here. You can also follow me on Twitter, Goodreads, LinkedIn, and Facebook. If someone shared this email with you, you can subscribe to it here.
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#155
July 1, 2022
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Friday's Elk, June 3, 2022

Geologists divide up Earth's history into eons, eons into eras, eras into periods. Someday, I imagine, cultural geologists will divide the history of the pandemic into time slices as well. But at the moment, in the late spring of 2022, the boundaries still seem too close to read in sharp detail. For now, each of us has to draw our own provisional stratigraphy. 

For me, January 2020 was the time of vague dread, followed by a February of preparing for the storm. March 2020 then arrived, bringing with it the horrible confirmation of just how bad the pandemic would be.

March 2020 to May 2021 was the age of hunkering down--and, for me, reporting like mad on vaccines and other scientific advances. May 2021 to July 2021 felt like the era of elation, followed by summer's disappointment of Delta. After an autumn lull, November marked start of the Omicron Period, which saw a giant spike of cases and deaths.

Geologists look for ways to divide one slice of time from another. A sprinkling of iridium, courtesy of an extinction-level asteroid impact 66 million years ago, marks the end of the Cretaceous Period and the start of the Eocene. It's hard to see any such dividing line marking the end of the Omicron Period. After peaking in January, cases in the United States dropped dramatically. But then they bumped up again in April, thanks to the evolution of some even fitter Omicron subvariants. The spring 2022 surge seems to have peaked. Strikingly, the rate of hospitalizations has remained far below that of the Omicron peak. Maybe the Omicron Period is over, but maybe not.

And if we are indeed entering a new chapter in pandemic history, we can't yet know what it is. Hopefully it won't be marked by the rise of a new, highly virulent strain. Instead, the coronavirus may just go circulating at a low level for a long time, repeatedly infecting us. Vaccines and previous immunity will reduce the damage that these repeated infections cause, but it's hard to say what it might mean for Long Covid. Millions of people already have it; how many millions more will join the ranks?

As for my own work, I feel as if I'm gliding into a new era. There's still plenty of Covid news to work on, and I have a couple stories in the works. But there's also enough bandwidth left over to take on some other subjects.

Not surprisingly, some of the stories I've worked on have been "Covid-adjacent." For example, here is a story I wrote about using machine learning to pinpoint animal viruses that might be especially prone to cause the next pandemic. I also wrote about how climate change is going to move animal hosts into new ranges, where their viruses will have the opportunity to hop into new hosts--raising the risk of even more new outbreaks.

But I've also had time to dive into some other subjects that I haven't really explored since the pandemic started. Here is a story I wrote about the discovery of a human-like tooth in a cave in Laos, dating back 150,000 years ago. It could potentially be key to understanding our enigmatic extinct cousins, the Denisovans. (I also took the opportunity in the piece to sing the praises of fossil teeth. They may not look as spectacular as a dinosaur femur, but every molar and incisor is an exquisite chronicle of evolution.)

I've also had a chance to read more books and even write a review. The book is by Frans de Waal, a primatologist who has done a lot in his research and books to change how we think about our fellow apes. His new book, Different, tackles the hot topic of gender. Although I have some reservations about parts of the book, overall I highly recommend it for a revelatory look at the roles of males and females in the world of primates.

I've even had some time to explore ideas for a new book--more about that later! Meanwhile, I had the honor of giving a lecture about Life's Edge for the Franke Program in Science and the Humanities at Yale.  You can watch the video--with lots of delicious details about death-defying water bears--here. 

In May, I received another honor: Poland's Smart Book of the Year Award for A Planet of Viruses. I gave a little thank-you speech at the virtual award ceremony (I turn up at about 25:35). That was followed by a longer interview as part of the Copernicus Festival, which you can watch here.

That’s all for now. Stay safe!

You can information and ordering links for all my books here. You can also follow me on Twitter, Goodreads, LinkedIn, and Facebook. If someone shared this email with you, you can subscribe to it here.
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#154
June 2, 2022
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Friday's Elk April 2, 2022


Greetings! I'm writing to you at yet another odd stage of the pandemic.

Here in the United States, at least, cases have dropped from their Omicron peak to lows we have not enjoyed since last summer. That's great, but we're also still waiting to see what the Omicron subvariant BA.2 has in store for us, now that it's become the dominant version of SARS-CoV-2 in the country. It's been doing all sorts of things in other countries: driving record spikes, creating middling plateaus, or barely registering as little bumps. Our relatively low rate of boosters among older folks does not bode well for us, but the epidemiologists I've been talking to still aren't ready to place their bets on what the rest of the spring looks like. Here's an updated explainer I put together about BA.2.

This spring has not seen an end to the coronavirus evolution-fest, with new forms of the virus popping up around the world. The viruses are recombining more and more--sometimes BA.1 and BA.2 are getting into the same cell; sometimes Omicron and Delta are mingling their genes. Here's a piece I wrote about why these hybrid viruses probably won't change the course of the pandemic, regardless of nicknames like "Deltacron" that sound titles for a science-fiction disaster movie.

Last month, Ben Mueller and I wrote about the question of Covid's origin. The occasion was a pair of preprints, whose authors argue that wild mammals sold in the Huanan market were the source of the pandemic. I followed up this month with a profile of one of the scientists, Edward Holmes, who has been studying the huge diversity of wildlife viruses for years and is continuing to document the threat that the wildlife trade poses to our health.

I've also been keeping the New York Times Covid treatment tracker up to date, as new drugs like Paxlovid go into use and old treatments like monoclonal antibodies become less effective against new variants. Two years into the pandemic, we are also finally getting some clarity from randomized clinical trials about treatments that have been the subject of fierce debate. Here's a story on a trial of Ivermectin, which failed to find any benefit for people sick with Covid.

Last year, I wrote about how the United Kingdom was leading the world in sequencing virus genomes and tracking new variants. Now, even as Britain is suffering from record high cases thanks to BA2 and Boris Johnson's "living with Covid" policies, the British government is cutting back on its surveys and tests. Here's a story I just wrote about how scientists fear that those moves may leave Britain depending on other countries for insights into the future evolution of the pandemic.

On the talk front:

I'll be at the University of Idaho on April 13 to talk about pandemic journalism. Details are here.

I also had a long chat with Lloyd Minor, the dean of Stanford Medical School, for his new podcast, the Minor Consult. We talked about all things Covid. You can watch it here.

That’s all for now. Stay safe!

(P.S. I created my new newsletter logo from an engraving of an Irish elk from Cassell's Natural History)

You can information and ordering links for all my books here. You can also follow me on Twitter, Goodreads, LinkedIn, and Facebook. If someone shared this email with you, you can subscribe to it here.
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#153
April 1, 2022
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Friday's Elk, March 4, 2022


I'm delighted to relay the news that the paperback edition of Life's Edge is coming out next week. If you're curious about the book, you can read this review from Siddhartha Mukherjee in the the New York Times Book Review. Here's an interview I did with Book Review editor Pamela Paul on their podcast. And, finally, here's a video of a lecture I gave to the Royal Institution, drawing on the book: "Are Viruses Alive?" 

On the reporting front, my colleague Ben Mueller and I reported on the latest analysis about the origin of SARS-CoV-2. Several lines of evidence point to the Huanan market in Wuhan as the place where the coronaviruses jumped from animals to humans--perhaps several times over the course of a few weeks in late 2019. Here's our piece.

That's all for now. Stay safe!

You can information and ordering links for all my books here. You can also follow me on Twitter, Goodreads, LinkedIn, and Facebook. If someone shared this email with you, you can subscribe to it here.
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#152
March 3, 2022
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Friday's Elk, February 4, 2022



After nearly two years of writing about Covid-19, I finally became part of the story.

When the virus known as SARS-CoV-2 arrived in the United States in early 2020, I fretted that it would find me and my family. After a year of hunkering down, vaccines let me relax a bit. By the summer of 2021, it became clear that the Delta variant could sometimes sneak past the vaccine's defenses, but a booster combined with masks and antigen tests gave me more confidence. Then Omicron came out of nowhere and slammed the United States with absolutely eye-popping numbers.

Yale, where I teach, offers PCR tests as part of their plan to keep their campus open. I took advantage of the opportunity to get tested once a week, regardless of my symptoms. (We would be collectively better off if we all could use such a service.) Some weeks I felt quite fine, and some weeks I felt a little run down or congested. But regardless of how I felt, I tested negative--until January 19.

On that day, as I drove to the test, I had a scratchy throat. I said to myself, "That can't be Covid." I thought it would be somehow more...dramatic. But Covid it was.

I was, ironically enough, working on a story about Omicron when I got an email informing me that I was harboring Omicron. My wife Grace (Covid-free) and I arranged the house so I could dive into isolation. My throat got a little scratchier, I developed a ticklish cough, and I began feeling a bit run down. But I had no fever, no shortness of breath, and no danger signs from a pulse oximeter. Mostly, I just kept working.

Having written about Covid testing, I was curious about how antigen tests would work on me now that I had Covid. They are less sensitive than PCR tests, but there's an upside to that: they're a good indicator of when you're actually infectious. PCR tests can come back positive very early in the disease, before people can spread the virus to others. They can also pick up bits of viral genes after the infectious window has closed.

Two days after my positive PCR test, I took an antigen test. It was negative. Intrigued, I tried the next day. Negative again! Same a day later. Puzzled, I arranged for a second PCR test. That was negative too.

I was happy that I got such a clear signal that, after five days of isolation, I was unlikely to be a threat to anyone. Now, a week later, I still have the remnants of mild cough, but it's nothing worse than I've experienced with colds and flus in the past. I am grateful that my vaccines (two shots of Pfizer and a Moderna boost) protected me from serious disease. But I'm also puzzled about how I got sick.

It's possible that my positive PCR test on January 19 was catching the tail end of a case of Covid. Back on January 8, Grace and I took our daughter to JFK to catch a flight, and we ended up sticking around for hours because she had to take a last-minute PCR test to get on the plane. While I kept a mask on the whole time, I was hanging around a big crowd of harried passengers waiting for test results.

Alternatively, the PCR test on January 19 may have caught the start of a very, very mild case of Covid. The virus multiplied enough to register on a PCR test, but my immune system crushed it so that it never reached levels high enough for antigen tests to catch. (My symptoms and the high rates of Omicron in Connecticut both make me discount the possibility of a false positive on my PCR test.)

One person's experiences with Omicron can't tell us all that much about it. But large-scale studies, such as one I wrote about in January, show that Omicron is sending a smaller fraction of its victims to the hospitals than Delta. One reason behind this differences is that some of its victims were vaccinated. Another reason may be that Omicron is intrinsically less likely to make people seriously sick--perhaps because it's poorly suited for invading the deep nooks and crannies of the lungs.

Paradoxically, though, this "mild" variant can be quite deadly. Over 2600 people are dying every day of Covid in the United States alone, and the majority of those cases are Omicron. The risk of dying from Omicron dramatically lowered by vaccines; boosters reduce the risk even further.

As soon as I learned about Omicron in November, it seemed very weird to me. It has a huge number of mutations. Its lineage appears to have split off from other SARS-CoV-2 lineages back in 2020, and yet it went missing till November 2021. As scientists look closer at Omicron, it remains deeply weird. A bunch of its mutations look like they should be lethal to the virus. But somehow, in combination, they've made it the most successful variant yet. I wrote about this perplexing evolution here. (The image at the top of this email was created for the story by the amazing NYT designer Jonathan Corum.)

Three months after it emerged, Omicron is still evolving. It consists of three lineages, called BA.1, BA.2, and BA.3. BA.1 got a head start and swamped the planet. But BA.2 turns out to grow faster than BA.1 and may be better at escaping vaccines. Fortunately, it doesn't look to be any more severe than BA.1. As I wrote a few days ago, BA.2 may slow down the ongoing fall in cases in countries like the United States but probably won't produce a new spike--and certainly won't strain hospitals more than BA.1 does.

That's all my Covid news (both personal and reportorial) for now. Here are two other things I'd like to draw your attention to:

I returned to the podcast Story Collider to tell a story about bats, Covid, and a search for inner balance in an unpredictable world. (In previous years, I've told stories for Story Collider about sleeping sickness and snapping turtles.)

Also, I'm delighted to report that Life's Edge: The Search For What It Means To Be Alive is a finalist for the PEN/E.O. Wilson Literary Science Writing Award. (She Has Her Mother's Laugh was also a finalist.)

That’s all for now. Stay safe!

You can information and ordering links for all my books here. You can also follow me on Twitter, Goodreads, LinkedIn, and Facebook. If someone shared this email with you, you can subscribe to it here.
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February 3, 2022
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Friday's Elk, January 7, 2022

I wish you all a Happy New Year. I also wish it wasn’t a year that kicks off with the rise of Omicron. Here’s hoping 2022 gets better as we move towards spring.


A month ago, when I sent out my last issue of Friday's Elk for 2021, Omicron was still a deep mystery. It was surging in South Africa, but it wasn’t clear if Omicron would perform the same way elsewhere. Things are very different now. By mid-December, early surges in Denmark and Norway hinted that Omicron was on its way to a global explosion. Before long, it was the dominant form across much of the world. A major source of Omicron’s success is its evasiveness. It can dodge antibodies--produced either by infections or vaccines--that would stop earlier variants. Omicron may also have adaptations that allow it to get from one person to the next more reliably than other variants, but that has yet to be determined.

As cases skyrocketed, hospitalizations rose at a slower pace. That decoupling suggested that Omicron might cause fewer cases of severe diseases. While Omicron may evade antibodies, T cells and other immune defenses--either from vaccines or previous infections--lower the risk of getting a really bad case of Covid. On top of that, Omicron is fundamentally different than other variants. It uses a different method to get into cells, one that works very well in the upper airway, but not so well deep in the lungs. 

All this adds up to a good-news/bad-news picture. It means that lots of people--both vaccinated and unvaccinated--will get infected. Some of them will end up in the hospital, the vast majority whom will be unvaccinated. The rate of daily cases, already breaking records, will continue to skyrocket through much of January before falling. Hospitalizations may increase as well. With hospital staffs hollowed out by sick staff in isolation, Omicron could push health care systems once more towards the breaking point.

The surge may also change the immune landscape. Preliminary studies suggest that Omicron infections create a strong immunity against Delta, but not vice versa. As Omicron surges, Delta--a variant that causes more severe disease--is vanishing. Immunity from Omicron infections may drive down that chances that people get sick in the future. It’s like spraying water on kindling. Flare-ups may become less likely in the months to come.

The uncertain state of medicine makes it even harder to predict our Omicron future. Boosters reduce the odds of infection and strongly reduce the risk of severe disease. But only 22 percent of Americans have gotten boosters yet. If that number rises quickly, fewer people will end up in hospitals. Many people could be kept out of the hospital if they can get two newly authorized antiviral pills--Paxlovid and molnupiravir. But they’re in desperately short supply. Meanwhile, Omicron resists the two leading authorized monoclonal antibody treatments, from Regeneron and Eli Lilly. It can still be treated with a third, called sotrovimab, but that too is in short supply.

If you prefer the spoken word to the written, I've talked to Michael Barbaro twice about Omicron on the Daily podcast.



I stepped away from pandemic reporting briefly to report on some sad news. The evolutionary biologist Edward O. Wilson died on December. Here is the the obituary I wrote for him for the New York Times. I’m grateful that my editors let me write in depth about Wilson's remarkable, controversial career. I went back through my own numerous interviews with him over the years and also talked to a number of scientists about their view on his legacy. That's not something that can fit in a few hundred words.

That’s all for now. Stay safe!

You can information and ordering links for all my books here. You can also follow me on Twitter, Goodreads, LinkedIn, and Facebook. If someone shared this email with you, you can subscribe to it here.
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January 6, 2022
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Friday's Elk, December 3, 2021

Image courtesy Rommie Amaro Lab/UCSD
Normally I send out this newsletter on the first Friday of each month. Before writing this edition, I went back to look at my November newsletter to refresh my memory, only to discover that I never got around to sending one out. My apologies!

In hindsight, I'm not that surprised that I blanked. On the first Friday of November, I was in Charleston to speak at their book festival. To get there, I took my first plane in almost two years. And when I spoke in front of a wonderful crowd at the splendid Sottile Theater, it was my first live audience in almost two years as well. Those experiences, plus a lot of shrimp and grits, made it a heavenly journey.

I then came home to a November that zipped by in a blur: booster shot, Thanksgiving, and news. So. Much. News. It's now been over a year since I reported on the first results of Phase 3 clinical trials showing that a Covid-19 vaccine would actually work. I had a foolish sense that after this milestone, the work of science writers would start winding down. The political, cultural, and business reporters could handle the pandemic story from there. But I'm still writing as fast as I can about the science of Covid-19, even as 2021 comes to a close.

On the vaccine front, I followed CureVac to the bitter end--at least for now. Meanwhile, Novavax finally scored its first authorization, in Indonesia, with more countries likely to come. Boosters won authorization, including Johnson & Johnson, but mix and match studies suggested that people who got J&J might do well to switch. But an even bigger trial, comparing seven vaccines including J&J, suggests that most combinations will work just fine--except maybe if Omicron flips over the table. Ah, Omicron. And beyond Covid-19, I looked at how companies like Moderna now using mRNA vaccines to tackle influenza.

Meanwhile, there are more developments in the mystery of Covid-19's origin. New bat viruses offer new evolutionary clues, and a close look at the early days in Wuhan points towards a market as the source.

And then there's the coronavirus itself. Scientists still don't have answers to a lot of basic questions, like what happens to coronaviruses inside the tiny drops of water that carry them from one person to another. A 1.3-billion atom simulation may shed some light.
Finally, in the good news department, the New York Times Book Review named Life's Edge a notable book of the year! Also, the Royal Institution has posted the video of a talk I gave based on part of the book, "Are Viruses Alive?" Watch it here.

That's all for now. Stay safe!

You can information and ordering links for all my books here. You can also follow me on Twitter, Goodreads, LinkedIn, and Facebook. If someone shared this email with you, you can subscribe to it here.

 
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December 2, 2021
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Friday's Elk, October 1, 2021

Image courtesy of David Bustos
Since my last newsletter in August, it feels as if we've entered bizarre new equilibrium. In the United States, roughly two thousand people a day are dying of Covid-19, a rate about as high as the first peak in spring 2020. Unlike back then, this new round of devastation is unfolding in a country where 65 percent of eligible people are vaccinated. If you had told me a year ago that this is how things would stand in September 2021, I don't think I'd have believed you.

Despite these terrible circumstances, I have been traveling, something I have not done for ages. My family has hit the road to see relatives and friends. Although we're all vaccinated, we still take precautions such as masking in indoor public spaces and taking rapid antigen tests before spending a lot of unmasked time indoors with other people. My wife and I dropped off our kids at college, where they are having a semi-normal school year, a thankful change from endless Zooming.

It remains difficult to see clearly what lies ahead--at a time when I had hoped that things would make more sense. The late-summer Delta surge is dropping in the United States, but it's hard to say how far it will fall. In some countries where the surge came earlier, cases eventually dropped, reaching remarkable lows. In Britain, by contrast, a sharp drop was followed by a quick bounce. While vaccinations unquestionably are preventing many deaths, the Delta variant is putting the unvaccinated at greater risk.

I've been continuing to write about the pandemic, but I've found time to look beyond this dreadful coronavirus. Instead of clinical trials for primary doses, I'm now reporting on data about boosters from Pfizer, Moderna, and Johnson & Johnson. In recent weeks I've also written about why we don't have tails, dreams of resurrecting woolly mammoths funded by Bitcoin billionaires, and ancient desert footprints that could change the way we think about how people came to the Americas.

I had hoped that this fall I'd be able to get back to giving talks in person, but it looks like book festivals are going to be rolling back to the realm of the virtual. The silver lining is that I can reach people without their needing to leave their house. I'll be talking about Life's Edge at the Brooklyn Book Festival on Sunday October 3 at 5 pm ET, and at the Brattleboro Literary Festival on October 17 at 2 pm ET. The following day, October 18, I'll be moderating a panel at the annual meeting of the National Academy of Medicine on how science has driven policy during the pandemic (it's open to the public). I'm still scheduled to appear in person at Charleston Literary Festival in November, but that might go virtual, too. And if you're interested, you can watch the video of a  recent conversation I had about A Planet of Viruses, hosted by the Science Writers of New York.

Finally, the UK edition of 
Life's Edge is out. Here's a lovely review from the Guardian, which arrived around the same time a stack of wonderful snake-covered books showed up at my house.


That's all for now. Stay safe!
 
My latest book is Life's Edge: The Search for What It Means to Be Alive. You can find information and ordering links for my thirteen other books here. You can also follow me on Twitter, Facebook, Goodreads, and LinkedIn. If someone forwarded this email to you, you can subscribe to it here.

Best wishes, Carl
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September 30, 2021
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Friday's Elk, August 13, 2021

Last month, in an appearance on the Daily podcast, I warned against assuming that the pandemic was over. The Delta variant was poised to potentially sweep across the United States. It might create a surge that might even require that the country return to masking and other measures to slow it down.

I sensed that the Daily host Michael Barbaro did not welcome the news. And I could sympathize. After months of mass vaccination and crashing cases, it was easy to believe that the coronavirus was now behind us. But by early July, there was plenty of evidence that the Delta variant might well push back those gains. It bore mutations allowing it to multiply quickly inside a host and then swiftly spread to new victims. It had already overwhelmed countries like India and the United Kingdom. Vaccines work well against Delta--especially against hospitalization from Covid-19--but only after both doses. Only about half of Americans are fully vaccinated, leaving the rest easy targets for the variant. 

I would have liked to have been wrong. But now, a month later, we are in the middle of a new wave. Hospitalizations are climbing fast across the southeast, with Florida shattering its record day after day for over a week now. The vast majority of people filling hospitals are unvaccinated--a group that includes an alarming number of children.

Yesterday alone, six hundred and sixteen people died of Covid-19 in the United States. With hospitalizations climbing, the daily deaths will continue to climb for days to come. If we're lucky, Delta may abruptly spike and fall, as it has in other countries. Or it may keep cutting lives short and leave thousands of more families devastated with grief. I certainly won't try to forecast its precise path. But it's clear that Delta demands that the United States renew its fight against the coronavirus even if we'd much prefer to believe that the fight is done.

This past month I also wrote about some other aspects of the pandemic. A team of scientists published a lengthy review of evidence about the origin of the coronavirus, concluding that a natural spillover was much more likely than an origin in a lab. Genetic sequences from early coronaviruses are invaluable to addressing this question, which led to the discovery that some sequences mysteriously disappeared from the Internet last year. Last month, they reappeared. 

As the months roll by, evidence is starting to emerge on the durability of vaccines from Moderna and Pfizer-BioNTech, guiding decisions about boosters to sustain their protection. Meanwhile, a promising protein-based vaccine from Novavax continues to perform well in trials. But the company is struggling to scale up its production and has had to put off its authorization plans for months.

I also managed to find some time to write about an entirely non-pandemic piece of science news. At long last, scientists have managed to sequence a complete human genome. Until now, their best efforts have been marred by huge gaps and thousands of errors. As I said in my recent interview on This Week in Evolution, this achievement will enable researchers to tackle some of the enduring mysteries about our genomes, such as why so much of it is made up of parasitic stretches of DNA.

Finally, I'm looking forward to appearing virtually at the Royal Institution later this month on August 26 to tackle the question, "Are Viruses Alive?" It's part of the publicity in the United Kingdom for the publication of the British edition of Life's Edge. The cover is serpentinely delightful.




That's all for now. Stay safe!

My latest book is Life's Edge: Searching for What It Means to Be Alive. You can find information and ordering links for my thirteen other books here. You can also follow me on Twitter, Facebook, Goodreads, and LinkedIn. If someone forwarded this email to you, you can subscribe to it here.

Best wishes, Carl
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August 13, 2021
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Friday's Elk, July 2, 2021

 
 
During the month of June, the pandemic took several different courses at once. In the United States, the overall average daily case rate continued its fall to levels not seen since March 2020. India experienced an even more dramatic crash. But other countries, from Russia to Indonesia to Liberia, experienced startling surges. The Alpha variant, which dominated the world in early 2021, ebbed away as the even faster-spreading Delta variant, first identified in India, swept across the globe. 

As a journalist, I spent June following some of the different courses that science took through the pandemic. Major trials for two of the most prominent vaccines delivered results. Novavax's trial in the United States put it on par with the most effective vaccines such as Moderna and Pfizer-BioNTech. Meanwhile, the German company CureVac, which I profiled in March, delivered dismal results, leaving experts to wonder if variants are a bigger threat to vaccine effectiveness than they thought, or if all RNA vaccines are not alike.

Meanwhile, other scientists were exploring how to use existing vaccines in new ways. Mixing vaccines could prove just as effective as two identical doses, if not more so. Boosters will probably become necessary at some point, but it's not clear when.

For all the progress with vaccines, their rollout remains woefully slow worldwide. People will continue getting sick with Covid-19, and there's still a huge need for cheap, easy, effective antivirals. In June, the National Institutes of Health embarked on a $3 billion program to develop Covid-19 pills. I wrote about how this program emerged out of Anthony Fauci's experience fighting HIV, and took a close look at some early contenders for the first Covid-19 pill to be shown to be effective in large randomized clinical trials.
 
While scientists are developing some effective weapons against SARS-CoV-2, the coronavirus still has many mysteries left for them to unlock.

--Why are new variants spreading so much more than previous ones? I wrote about a new study of Alpha that suggests an important part of its secret to success is an ability to disable an infected cell's alarm system. Delta's secrets remain to be unlocked.

--Are coronaviruses a new kind of plague? It's true that three out of the seven known human coronaviruses all emerged in the past 20 year: SARS, MERS, and Covid-19. But a new study has found a signature of a coronavirus epidemic in East Asia over 20,000 years ago.

--How did the pandemic start? The controversy over the origin of SARS-CoV-2 has drawn huge attention some pretty esoteric corners of virology. James Gorman and I wrote about the long history of debates over "gain of function" experiments. We also interviewed the virologist who emailed Anthony Fauci early in the pandemic as he took an early look at the genome of SARS-CoV-2. And I wrote about another virologist who discovered 13 genetic sequences from early coronavirus infections squirreled away in the recesses of Google Cloud.

June also brought the good news that the New York Times won the Pulitzer Prize for Public Service, in honor of its coverage of the pandemic. Working with all the reporters, designers, data wranglers, and editors at the Times has been one of the highlights of my career in science writing. I'm particularly grateful for being able to work on something useful at a time when it was so easy to feel helpless. It was also heartening to see the Pulitzer Prize give so much recognition across the board to science writing, with The Atlantic's Ed Yong winning in the explanatory journalism category and STAT reporters Helen Branswell, Andrew Joseph, and the late Sharon Begley named as finalists in the breaking news category. Many others have also been working hard to break new stories and explain murky science during the pandemic: kudos to all.

The pandemic will likely continue to take up a lot of my waking hours in the months to come. There will be more stories to tell about the coronavirus. But I also had the opportunity in June to dive into some fascinating 
non-pandemic news.

--A 140,000-year-old skull hidden in a well in China for over eight decades may be a new species, or perhaps is the face of Denisovans that scientists have been hunting for years.

--Long-time readers may recall two stories I've written over the years about the mind's eye--and what it's like to lack one, a condition known as aphantasia. I revisited this science this June, discovering that some people have the opposite of aphantasia, known as hyperphantasia. 

In the months ahead, I'll be giving more talks, some about Life's Edge and others on other subjects. On July 22, I'll be joining historian Brandy Shillace for her new Peculiar Book Club. She describes it a club that will feature "your favorite authors of strange history, medical marvels, and weird science. In true book-club style, you will meet the author and participate in the discussion." Her other guests include Mary Roach, Sam Kean, and more.

In the fall, festival organizers are starting to make plans for in-person events. I'll be at the Brattleboro Literary Festival in October, and in November I'll be at the Charleston to Charleston Literary Festival in South Carolina. I'll keep you posted on additional events as they fall into place.


That's all for now. Stay safe!


My newest book is Life's Edge: Searching for What It Means to Be Alive. You can find information and ordering links for my thirteen other books here. You can also follow me on Twitter, Facebook, Goodreads, and LinkedIn. If someone forwarded this email to you, you can subscribe to it here.

Best wishes, Carl
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July 1, 2021
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Friday's Elk, June 4, 2021

I've been a fan of Atlas Obscura ever since it started out as a web site cataloging the world's weirder places. Since then, it has grown into a far bigger operation, offering books, trips, and other features. Recently they've put together a series of online courses. I'm delighted to announce that next month I'll be teaching a course called "The Meaning of 'Life.'"



Here's the course description: 


What does it mean to be alive? Join journalist, author, and New York Times columnist Carl Zimmer to discover why the answer is not so simple. Over the course of three sessions—with independent fieldwork excursions and optional assignments in between—we’ll journey through strange experiments that have attempted to recreate life, surprising examples of life around the world, and the slippery and ever-shifting qualifications for being alive. We’ll search for life in unexpected places, venturing into the inhospitable homes of extremophiles and peering into the worlds of other mind-boggling life forms. Along the way, we’ll begin to understand how the question “what is life?” is not merely a philosophical one, but one that shapes real-world decisions, our behavior, and the course of human history. By the end of the course, you’ll be developing your own ideas about where to draw the line between the living and the non-living, and learning to see a world teeming with life—even in the most unexpected places.

We'll be meeting for three 90-minute class. I'll lead us through some exercises in challenging our own notions of life, and coming up with better ones. We'll share some life-related homework, and have a visit from a scientist who examines life in some of the weirdest corners of the planet. And there will be lots of time for conversation. My goal is to create a great experience both for people who have read Life's Edge (bring your questions from reading it!) and for those who have yet to do so. You can find more information and register here.

The pandemic has continued to dominate my working life this past month, even as vaccines help drive down cases in the United States at a remarkable clip. The slow rollout of vaccines to the rest of the world--combined with the swift spread of variants--means that the global toll of Covid-19 remains brutal, and that the pandemic remains the world's top science story.

Here's a deep dive I co-authored with Apoorva Mandalvilli about how the variants bubbled up in America--but didn't wreak the havoc that many feared they would. I also wrote about the resurgence of attention to the mysterious origins of SARS-CoV-2 here, here, and here. You can also listen to an interview I did with New York public radio host Brian Lehrer about the mystery here.

But I also found time to write about a cool non-covid study, in which scientists used a technology called optogenetics to implant light-sensitive proteins in a blind man's eye. One day, he could suddenly see the stripes in a crosswalk near his house. I very much look forward to spicing up the journalistic buffet with other stories beyond the coronavirus this summer!

That's all for now. Stay safe!



My new book is Life's Edge: Searching for What It Means to Be Alive. You can find information and ordering links for my thirteen other books here. You can also follow me on Twitter, Facebook, Goodreads, and LinkedIn. If someone forwarded this email to you, you can subscribe to it here.

Best wishes, Carl
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June 3, 2021
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Friday's Elk, May 7, 2021

When my wife Grace and I moved to Guilford, Connecticut, 18 years ago, we were grateful that it was a town where you could walk for a reason. To go to the library. To get a pizza. To get your hair cut. To some people, those may seem like petty things. But for us, they meant a great deal.

Last March, our lives were disrupted in many ways. We stopped traveling by plane and train. Our time with extended families was mostly restricted to phone calls and Zoom sessions. But the nearby disruptions were just as bad. Trips into stores were quick, no-nonsense errands. The rest of our lives within walking distance began to lose out in our risk-benefit calculations. After a while, the isolation began to feel normal. Now that I've gained immunity, it takes effort to rediscover the town all around me.

Today's small victory was a haircut at the Village Barber Shop. I still wore a mask inside, but I no longer felt keenly aware of the invisible aerosols swirling around me. All the old rituals felt new. The smock, covered in images of combs, hairdryers, and mirrors, going around my neck. The chat about this year's high school graduation plans. The buzzing clippers and the straight-edged razor removing a year's worth of hairy chaos.

These experiences feel like unearthing buried treasures. I relish them, even as I think about how bad the pandemic remains. Worldwide, the average number of daily new cases remains far above the summer peak, driven largely by the catastrophic surge in India. A country like India should be far along in vaccinating its citizens--after all, India has become a vaccine-producing powerhouse in recent years. But their campaign has slowed to a crawl, leaving millions at risk of infection.

Vaccines were the focus of much of my work this past month for the New York Times. My colleagues and I broke the story when
the U.S. government recommended a pause for the Johnson & Johnson vaccine. We went on to write about the review of reports of rare blood clots. I wrote about some of the preliminary research on why vaccines such as J&J and AstraZeneca might lead to such side effects in a very few number of cases. I talked about the disruption on the Daily. Soon the pause was lifted. But the effect was profound. Before the pause, the use of Johnson & Johnson's vaccine was swiftly rising. Since the pause lifted, its uptake remains low.

Meanwhile, scientists have been debating about how best to use the limited number of vaccines the world has. I wrote about how some countries are choosing to delay second doses to get first doses to more people.

Behind the currently authorized vaccines, a second wave of vaccines is coming. Clinical trials may reveal that some of them are superior to existing ones, in terms of effectiveness, cost, or ease of use. I wrote about a structural biologist who has discovered what could be a potent new kind of vaccine, which could be grown cheaply in chicken eggs. I also wrote about an RNA vaccine that might join the ranks of Moderna and Pfizer-BioNTech. And as my colleagues have done reporting on their own on other developments in the world of vaccines, I've been organizing the news on the New York Times vaccine tracker, where we are now following  90 vaccines through clinical trials.

This month I also had a number of delightful conversations about Life's Edge, on Science Friday, Quirks and Quarks, RadioWest, and Good Chemistry. And thanks to AudioFile Magazine for an Earphones Award for the audiobook of Life's Edge. All credit goes to Joe Ochman for his agile spoken-word skills. Here's the Audible version. Other audiobook outlets can be found here. 


That's all for now. Stay safe! 

You can find information and ordering links for my fourteen books here. You can also follow me on Twitter, Facebook, Goodreads, and LinkedIn. If someone forwarded this email to you, you can subscribe to it here.

Best wishes, Carl

 
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May 6, 2021
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Friday's Elk April 3, 2021

Lots to relay in this issue of Friday's Elk, including news on two books. So let's dig in!

I've written a new edition of A Planet of Viruses, which has just come out. It has the same micro-format of the original edition a decade ago: twelve essays on twelve of my favorite viruses. But I've updated it throughout with new scientific research. Most significantly, I've written a chapter on Covid-19, drawing on my reporting for The New York Times over the past year.

The book also has a new look, courtesy of an old friend. When I turned ten, my family moved to the rural fringe of western New Jersey, where I didn't know a soul. Someone told my parents that a kid like me who was always writing stories and drawing comic strips should meet another ten-year old there named Ian Schoenherr, who drew pictures of Willy Wonka and such. We've been friends ever since. Ian has gone on to illustrate a long string of books, while I've been writing others. This is the first time he has illustrated a book of mine, and I couldn't be more pleased. You can order the third edition here.
 

Life's Edge: Podcasts and More

This weekend, the New York Times Book Review put Life's Edge on the cover, with a review from Siddhartha Mukherjee, author of Emperor of All Maladies and The Gene. It's a career first for me, so I'm inexpressibly grateful.


The Washington Post reviewed Life's Edge as well, writing, "The pleasures of Life’s Edge derive from its willingness to sit with the ambiguities it introduces, instead of pretending to conclusively transform the senseless into the sensible.” 

I also had an hour-long conversation with Meghna Chakrabarti, host of National Public Radio's On Point. Listen here. Pamela Paul, the editor of the New York Times Book Review, hosted me on her podcast as well.

You can order the book here.
 

 Not Missing My Shot

After writing for months about the Pfizer-BioNTech vaccine, it's weirdly elating to get their messenger RNA pumped in my shoulder. Looking forward to full immunization in mid-May. 

That's all for now. Stay safe!

You can find information and ordering links for my fourteen books here. You can also follow me on Twitter, Facebook, Goodreads, and LinkedIn. If someone forwarded this email to you, you can subscribe to it here.

Best wishes, Carl

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April 2, 2021
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Friday's Elk, March 19, 2021

It's been ten days since the publication of Life's Edge. For the past couple weeks, I've taken a break from covering the pandemic for the New York Times to work on the book launch. Here are a few highlights so far:

--Slate published an excerpt about how brain organoids challenge our notions of how life begins

--Quanta published another excerpt on how philosophers can help biologists in their struggle to define life. One option: give up!

--I reposted my Sunday Review essay about viruses and life on Medium.

--Science News reviewed Life's Edge: "From the struggle to define when life begins and ends to the hunt for how life got started, the book offers an engaging, in-depth look at some of biology's toughest questions."

--Biologist and author Rob Dunn reviews the book in Science: "By the end of this book, I felt challenged as a biologists to pull together my colleagues to talk about the big issues related to...the origins of life, and the margins of life."


--I joined Walter Isaacson on Morning Joe on MSNBC to talk about our new books.

--I spoke on Wisconsin Public Radio about Life's Edge.

--Looking forward, please join me next Thursday in a talk hosted by my favorite local book spots: Breakwater Books in Guilford, Connecticut, and the Guilford Free Library. Register here.

--Since I can't sign books for people in person at live events, I'm happy to send autographed bookplates. Please provide some kind of "proof of life" that you bought the book (on Twitter, for example), and contact me via carlzimmer.com




That's all for now. Stay safe!


My next book is Life's Edge: Searching for What It Means to Be Alive. You can find information and ordering links for my thirteen other books here. You can also follow me on Twitter, Facebook, Goodreads, and LinkedIn. If someone forwarded this email to you, you can subscribe to it here.

Best wishes, Carl
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March 18, 2021
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Friday's Elk, March 5, 2021

I don't know what it's like for you, but this March is giving me some hesitant hope. Maybe this has something to do with it:

There are four days left before the book comes out, but today--with a hard copy to clutch--feels like the day the book comes alive (forgive the pun). 

If you'd like to hear more about Life's Edge, I have a growing number of talks coming up. Here's the list so far:

March 10, noon PT/ 3 pm ET: The Commonwealth Club. "What It Means To Be Alive." Register here. I'll be in conversation with Rachel Becker of CalMatters. This talk will also be broadcast on C-SPAN. The video will be posted here.

March 11, 7 pm ET: Science Writers of New York. Register here.

March 12, noon MT/ 1 pm ET: Radio West, KUER. Listen live here.

March 17, noon ET: "The Coronavirus Unveiled: What Covid-19 Is Teaching Us About Life." Science Journalist in Residence, University of Florida. Register here.

March 18, 1pm ET: Reddit AMA.

March 25, 7 pm ET: Breakwater Books and the Guilford Free Library. Register here.

And if you'd like to sample some of the book, check out this essay in the Sunday Review in the New York Times, "The Secret Life of a Coronavirus."

Vaccines Versus Variants

Another reason for my optimism is the accelerating pace vaccination in the United States. I was startled to learn that I will be able to register for a vaccine on March 22. I had mentally prepared myself to hunker down, unvaccinated, till the summer. The Biden administration expects now to have enough vaccines by May to vaccinate all American adults.

Part of the reason for the vaccine surge was the authorization of Johnson & Johnson's single-shot vaccine at the end of February. Having followed this particular project from its mouse-and-monkey days, it was astonishing to be able to write up some of the final stories about its journey into people's arms less than a year later. There's been a lot of discussion about the efficacy of the J&J vaccine, which was an opportunity to delve into the nuances of this scientific concept--a concept we all need to get familiar with as more vaccines become available.

Tempering my optimism is the continuing spread of variants. These lineages are just a few months old, and so we're just getting acquainted with them. Some are definitely highly contagious, while some could potentially lower the efficacy of vaccines. Here's a story I wrote about the first deep look at a particularly mysterious variant, called P.1, which devastated a city in Brazil at the start of this year and has since spread to the United States and 23 other countries. Meanwhile, a dominant variant in California has scientists unsure whether it poses a big risk or not. This uncertainty is an inevitable byproduct of the country's improving surveillance of variants. The more we look for more mutations, the more we'll find. But it will take time to figure out which of the new mutations matter.

Science has delivered us Covid-19 vaccines in record time, and it has the potential to solve the problem with variants, too. Vaccines against variants are now in development, and the FDA is setting up guidelines to ensure that they can get authorized speedily without sacrificing safety. Don't be surprised if you need a booster this fall to keep you healthy.

On Thursday's episode of the Daily podcast, I talked 
with host Michael Barbaro about the complex spring and summer that lie ahead of us. You can listen here.

That's all for now. Stay safe!

You can find information and ordering links for my books here. You can also follow me on Twitter, Facebook, Goodreads, and LinkedIn. If someone forwarded this email to you, you can subscribe to it here.

Best wishes, Carl
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Friday's Elk, February 27, 2021

This is a quick note to draw your attention to a piece I've just published that I'm very proud to share. Tomorrow's Sunday Review in the New York Times features a long essay I adapted from my new book Life's Edge. It's called "The Secret Life of a Coronavirus."

In my essay, I touch on a couple of the big questions in my book: what does it take to be alive, and what are we to make of the things that don't quite meet our requirements? Our current pandemic is the work of one such hard case.

I hope you enjoy the essay. If you like it, there's a lot more to be had in my book, which is coming out in ten days. You can pre-order it here. (FYI, pre-ordering is a great way to support all the authors you like, because it helps draw attention to their books in the first week after they're published.) 
The illustration for the article, by Khyati Trehan, is gorgeous (and even more so when it comes to "life" on the NYT web site.)


That's all for now. Stay safe!

You can find information and ordering links for my thirteen other books here. You can also follow me on Twitter, Facebook, Goodreads, and LinkedIn. If someone forwarded this email to you, you can subscribe to it here.

Best wishes, Carl
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February 26, 2021
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Friday's Elk, February 19, 2021

Life Finding A Way

On a snowy February afternoon almost exactly a year ago, I took my final pre-pandemic road trip. I drove to Albany, where I met a pair of wildlife biologists named Carl Herzog and Katelyn Ritzko. Together we traveled on into the Adirondacks, stopping at the end of a road in the woods. Getting out of the car, we hiked a snow-covered trail until we reached a half-frozen stream. There we stopped to suit up in neoprene chest waders. We put on helmets, switched on headlamps, and stepped into the stream to make our way into a flooded graphite mine. 

“Tripping and falling is the biggest threat,” Herzog said as the darkness closed around us. “You don’t ever want to touch the ceiling.”
I had come to the mine to pay a visit to its inhabitants. Clinging to the walls were bats, looking like furry pears glistening with beads of moisture. They held perfectly still in our headlamps as they hibernated. The temperature of their bodies matched the cool temperature of the mine. They had been hanging on those slick walls for over four months and would still be there weeks after my visit.

Yet the bats were different from the chunks of rocks lying on the floor of the mine, from the timbers still propping up the passageways. Inside their bodies, the molecules making up the bats were balancing each other in a delicate dance of homeostasis. In other words, they were alive.

Fortunately, I got out of the mine and back home safely. There I wrote about the trip--and what it showed me about life--in a chapter of Life’s Edge: The Search for What It Means To Be Alive. I’m looking forward to sharing these experiences when the book comes out on March 9. Since my last newsletter, Booklist gave Life’s Edge a starred review, writing, “Zimmer invites us to observe, ponder, and celebrate life’s exquisite diversity, nuances, and ultimate unity.”

Next month I’ll be having a series of live events where I’ll be talking about the book. On March 10 at noon PST / 3 pm ET, the Commonwealth Club in San Francisco will host a conversation about Life’s Edge between me and environmental reporter Rachel Becker. You can sign up here. 

There’s still time to enter the Goodreads giveaway. Visit this page by March 1 and click the “Enter Giveaway” button for a chance to win one of fifteen finished hardcover copies of Life’s Edge. (Only U.S. residents are eligible, I’m afraid.) If that kind of uncertainty is just too much to handle, you can pre-order it here.
 


Brain Organoids as Evolutionary Time Machines

The cover of Life’s Edge features another strange form of life called brain organoids. These pea-sized spheres, made of hundreds of thousands of neurons that develop from a single cell, can produce electrical impulses much like brain waves. 
I first wrote about brain organoids back in 2018, and I explore them further in Life’s Edge. A lot of our notions about human life are wrapped around our brains. Brain death is the legal definition of death, for example. Now brain organoids tangle up those definitions in fascinating ways.

Last week I wrote in the New York Times about a new frontier in brain organoid research: scientists are using them to explore our evolutionary past. Researchers have edited a gene in brain organoids, turning it back into the form it had in our ancestors over half a million years ago. Remarkably, the brain organoids turn out very different from normal ones. That difference may hold clues to how we became uniquely human.

 

Biden Versus the Variants

The continued drop in new Covid-19 cases in the United States is heartening. In early January, the country was averaging over 250,000 new cases at the peak. Now the daily average has fallen below 73,000--a seventy percent drop.

But it’s easy to lose sight of just how bad things remain. We’re closing in on half a million deaths from Covid-19. Before this horrific third wave, the previous record for average daily cases had been over the summer. But the summer peak never reached 67,000 cases a day on average--6,000 cases below the rate that seems so encouraging now. This pandemic is still out of control.

There aren’t enough vaccinated people to explain the drop over the past several weeks. It’s likely a post-holiday shift in behavior that deserves the credit. People may be taking masking seriously. They may be cutting down on the visits to restaurants and house parties that were driving super-spreader events in late 2020. We can hope that these efforts continue, and that cases continue to drop. But variants are becoming a looming threat, with the potential to reverse that progress.

B.1.1.7, first discovered in the United States at the end of December, is now exploding just as it did earlier in the United Kingdom where it was first found, as well as Denmark, Switzerland, and other countries. I recently reported on a study that found B.1.1.7 is doubling every ten days in the U.S. Preliminary studies hinted the variant was not just more contagious but more lethal. More research is now supporting that view.

Two other variants, called B.1.351 and P.1, are also worth concern--not just because they seem to be more contagious, but because they can dodge some of the antibodies produced by vaccines. And more variants are gaining new mutations all over the world. I wrote about the discovery of seven variants in the United States alone, all gaining a mutation at the same spot in their genome.

All this evolution is making it more and more challenging to keep track of the variants, so Jonathan Corum and I have created a variant and mutation tracker to help you keep these critters sorted.

Just a couple months ago, coronavirus variants were a theoretical concern. Now they are front and center. Vaccine makers are preparing to test out B.1.351 boosters. Others wonder if maybe vaccines could have a broader impact, so that we don’t have to continually play catch-up with evolution. Indeed, there are other coronaviruses lurking in animals that may spill over in years to come. I wrote about some preliminary research into the possibility of a “pancoronavirus” universal vaccine--one shot to rule them all.

The first step, scientists agree, is to get a better fix on the variants. Until now, the United States has done relatively little genome sequencing necessary to track their origin and spread. The efforts are going on in a patchwork of underfunded labs. My colleague Noah Weiland and I wrote Wednesday about an announcement from the White House of a $200 million “down payment” on variant surveillance. The Covid-19 relief package making its way to a vote in Congress has another $1.75 billion in funding to set up a far more massive program. It’s likely that we’ll need it not just to get through the next few months, but to handle the emergence of new variants for years to come.

 

The Vaccine: Conquering Covid

Last night, the Discovery Channel aired a 90-minute documentary about the scramble for a Covid-19 vaccine. My favorite part was the deep backstory on mRNA vaccines, featuring Katalin Karikó and Drew Weisman, a pair of scientists who toiled in obscurity for years on the concept. Now they might well win a Nobel Prize, plus the satisfaction of watching millions of people get protected thanks to their work. 
I provide some commentary along the way from my backyard. Nobody who’s not in my pod is going to hang out inside my house until we’re all vaccinated--not even a film crew!

The show is streaming now on discovery+.
 

That's all for now. Stay safe!


You can find information and ordering links for my thirteen other books here. You can also follow me on Twitter, Facebook, Goodreads, and LinkedIn. If someone forwarded this email to you, you can subscribe to it here.

Best wishes, Carl
 
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