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May 4, 2026

OoL digest — May 4

This week we have 19 new papers relevant to the origins of life. Enjoy!

Please note that inclusion of these papers reflects topic, not quality, and that evaluating scientific merit is out of scope for this newsletter.

AI-detection tools (e.g. Pangram) can also be useful when first assessing new publications.


Artificial Life

Toward life with a 19–amino acid alphabet through generative artificial intelligence design
Liu et al. — Science


Astrobiology

In Situ Analytical Chemistry Laboratory for the Exobiology Extant Life Surveyor
Drevinskas et al. — ACS Measurement Science Au

Astrobiological Implications of Lava Flows Superposed on Martian Glaciers: Assessment of Formation and Fate of Meltwater, Moulin Formation, Induced Transition to Wet-Based Glacial Conditions, and Ice-Flow Velocity Enhancements
Fastook et al. — Astrobiology

The effect of spectral resolution on biosignature detection via reflected light observations of the Earth through time
Gilbert-Janizek et al. — preprint

Defined Mars Media (DMM), a chemically defined simulant of the soluble macro- and micro- nutrients in Mars regolith for use in biological research
Greene et al. — preprint

Is constitutive red-shift an advantage for oxygenic photosynthesis under M-dwarf starlight? Insights from Acaryochloris marina sp. str. Moss Beach
Liistro et al. — preprint

Lipid Biomarkers in Microbialites from a Maar Lake: An Astrobiological Study of Biomarker Preservation under Mars Analog Conditions
Martínez-Pabello et al. — Astrobiology

Rover‐Induced Mineral Transformations: Extent of the Effect for the Mars Science Laboratory and Opportunities for Future Landed Mission
Meusburger et al. — Journal of Geophysical Research: Planets

Detecting Fundamental Chiral Biosignatures in the Ultraviolet Polarization Spectrum
Sparks et al. — Astrobiology

The science from asteroid sample return missions
Tasker et al. — Contemporary Physics


Astrochemistry

TMC-1: probing the onset of chemical complexity in space
Agundez et al. — preprint

As above, not so below: Ion fractionation in planetary analog ices
Buffo et al. — Science Advances


Biochemistry

The master molecule that built biology: How water shaped the chemistry of life
DiGiacomo et al. — Protein Science

Bayesian Rate Inference for Sequence Motif Dynamics in Systems of Reactive Nucleic Acids
Harth-Kitzerow et al. — preprint


Biophysics

Topology as biological code: information-driven evolution of neighborhood structures in self-organizing cellular systems
Chen — BioSystems


Computational Biology

Algorithms for Enumerating Irreducible and Closed Autocatalytic Sets
Hordijk — preprint


Microbiology

Methanogens Through Time and Space: Impact on Earth’s Planetary Evolution and Biogeochemistry
Tomko et al. — Geosciences


Planetary Sciences

Astrochemical Inheritance of Terrestrial Planets Water from Local Wet Silicates
Boitard-Crépeau et al. — Monthly Notices of the Royal Astronomical Society

Equifinality of Venus-like CO$_2$ Atmospheres
Constantinou et al. — preprint

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