Archive • Bioinformatics and more • Buttondown

Using docker for reproducibility, workflows and more

February 7, 2023

1 - Controls and weird results from polls Polls are a resource to understand some fundamental aspects of our society. The question is, are they the right...

Batch effects, experimental design and more

November 11, 2022

# 1 - Removing batch effects on RNA-seq data Batch effects are everywhere. The paper proposes a new method for batch effect removal and normalization for...

Causality in observational data, dichotomization issues and more

1 - CausalImpact Drawing causal conclusions based on observational data is a hard task. With that in mind, a google team developed CausalImpact, a causal...

Quarto, the table 2 fallacy and more

1 - Quarto: the next generation of R Markdown R Markdown is a tool that helps data scientists, researchers and data enthusiasts to code and produce beautiful...

AI or statistics, personalised medicine and more

1 - AI or statistics: what is the right terminology and domain of application? Should we use artifical inteligence (AI) or statistics? Are they even...

Ladder-seq, association of genes with cancer and more

February 19, 2022

1 - A new approach to RNA-seq: Ladder-seq As time goes, past technologies are refined. This is the case with (bulk) RNA-seq. Ladder-seq is a new technology...

An explanation of p-values, effect sizes and more

October 18, 2021

1 - p-values, misconceptions and different approaches There are a lot of critics on how scientists have been using p-values. In the blog post below they...

History of DESeq2, biostats with Frank Harrell and the surprises of infinity

September 7, 2021

1 - History of DESeq2 and more In this podcast, Michael Love talks about the development and concepts behind DESeq2. Moreover, the podcast gives us a glimpse...

#1 - First newsletter! Hypothesis in science, mutation signatures and more.

August 11, 2021

1 - Mutations and bioinformatics The discovery of new mutations and how they affect patients has been heavily studied in cancer research, with new tools...