Base By Base · weekly digest

Week of May 04 – May 11, 2026

6 episodes this week. Each one audited claim-by-claim against the original paper.

Editor's note: [write 1–2 sentences on what stood out across the week's science]

Issue 363 · Nature Communications Cell-free DNA size deconvolution resolves nucleosomal origins and reveals tumor-associated fragmentomic alterations Zhou Z · QC: Verified · ♪ Entropy Between the Beats Read & listen → · Direct audio

Issue 362 · PNAS D614G reshapes allosteric networks and opening mechanisms of SARS - CoV - 2 spikes Kearns FL · QC: Verified · ♪ When the Bridge Breaks Read & listen → · Direct audio

Issue 361 · PNAS Chiral inversion mutagenesis identifies geometrically constrained residues within self - associating low - complexity domains Beckner RL · QC: Verified · ♪ Mirror-Hands on the Backbone Read & listen → · Direct audio

Issue 360 · PNAS An inverse correlation between structural linguistic and human genetic diversity Graff A · QC: Verified · ♪ Entropy in the Quiet Read & listen → · Direct audio

Issue 359 · PNAS Computational design of an ultrapotent deltacoronavirus miniprotein inhibitor Avery NG · QC: Verified · ♪ MB11 at the Door Read & listen → · Direct audio

Issue 358 · Human Genetics and Genomics Advances Biallelic variants in CHCHD4 are associated with combined OXPHOS defect leading to mitochondrial disease Mantecon M · QC: Verified · ♪ Import the Light Back In Read & listen → · Direct audio

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